A Crucial Pattern Behind Long COVID May Have Been Identified

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A Crucial Pattern Behind Long COVID May Have Been Identified
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The findings of this new study suggest four of those mechanisms might be interconnected, and could explain the cognitive difficulties and memory loss people with long COVID. Not only that, the study could point the way toward possible treatments if the results are replicated in larger cohorts.

The connection they propose goes like this: lingering viral material could trigger the body's immune system to pump outThis drives inflammation, which limits the absorption of tryptophan, an amino acid used to make serotonin, in the gut. "Our findings suggest that several of the current hypotheses for the pathophysiology of long COVID might be linked by a single pathway that is connected by serotonin reduction," Maayan Levy, University of Pennsylvania microbiologist and senior author of the study,In mice, low serotonin levels and reduced vagus nerve activity from a viral infection resulted in the animals performing worse on memory tests.

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