In hospitalized patients with acute kidney injury, a BUN/creatinine ratio less than or equal to 12 suggests the diagnosis of acute tubulointerstitial nephritis, finds a study published in BMCNephrol
An experienced nephrologist performed all of the kidney biopsies. Prior to the procedure, all the patients were normotensive, and kidney size and anatomy were evaluated via ultrasound. Following the localization of the left kidney inferior pole, the puncture site was marked, the skin was prepared with chlorhexidine, and 1% lidocaine was used for local anesthesia.
Histologically, AIN was defined as interstitial edema and interstitial infiltrate consisting primarily of mononuclear or polymorphonuclear leukocytes. Tubulitis was defined as the invasion of the tubular basement membrane by inflammatory cells [In accordance with their respective distributions, continuous variables were expressed by the mean ± standard deviation or the median with interquartile range. The normality of the distribution was evaluated by using the Kolmogorov‒Smirnov test.
The optimal BCR value for discriminating AIN was identified by using a ROC analysis. The Youden point was selected to maximize the sensitivity over the specificity. The bilateral p-value for statistical significance was established at < 0.05. The statistical analysis was performed by using R in the R-Studio.Five hundred thirty patients diagnosed with AKI were assessed, of whom 42 patients satisfied the inclusion criteria and underwent a percutaneous renal biopsy (Fig.
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