High-throughput quantification of cell type-specific activity of cis-regulatory elements at the single-cell level promises a better understanding of how noncoding sequences and their variants function. NBThighlight
S.Z. and B.A.C. are inventors on a pending patent filed by Washington University in St. Louis which may encompass the methods, reagents and data disclosed in this manuscript. B.A.C. is on the scientific advisory board of Patch Biosciences. The remaining authors declare no competing interests.thanks Bas van Steensel, Rickard Sandberg and the other, anonymous, reviewer for their contribution to the peer review of this work.
of the single-cell transcriptome from the mixed-cell experiment. 105 out of 3417 cells are labeled by both K562 and HEK293 cell genes. of the mixed-cell experiment with cells marked by other representative markers for K562 and HEK293 cell expression. Histogram of the number of plasmids transfected into K562 cells and HEK293 cells. Histogram of the mean number of rBC per cBC per cell for K562 cells and HEK293 cells. (
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