The incident is on the A64 between Tadcaster and York, North Yorkshire Police say.
A major North Yorkshire road is closed in both directions after a "serious collision", according to police.
The A64 between Tadcaster and York has been shut following the incident, which took place at 01:20 BST on Monday. Collision investigation work is to take place throughout the morning's rush hour with the road remaining closed, North Yorkshire Police said.
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