Since the 1950s, researchers have used a famous method invented by Wallace Coulter known as 'flow cytometry' to characterize different types of immune cells in research studies and in blood samples from human individuals.
Wyss Institute for Biologically Inspired Engineering at HarvardJul 30 2024 Since the 1950s, researchers have used a famous method invented by Wallace Coulter known as " flow cytometry " to characterize different types of immune cells in research studies and in blood samples from human individuals. This has enabled a much deeper understanding of immune cell development as well as new ways to assess human health and diagnose various blood cancers.
"ACE helps to close a crucial gap in cytometric analysis: by enhancing the sensitivity of mass cytometry, it enables a single cell analysis platform that simultaneously achieves high sensitivity, high multiplexing, and high throughput.
ACE creates a scaffold with multiple binding sites for short metal isotope-carrying "detector strands." In addition, by branching the synthesis of the scaffold strand, the researchers could further increase the method's sensitivity for the detection of rare proteins. Linear ACE on average provides a 13-fold signal amplification while branching ACE allows an initially unamplified signal to be increased more than 500-fold.
The team used the same ACE-enhanced antibody panel to investigate a phenomenon known as "injury-induced T-cell paralysis." T cells experiencing injury in their environment, such as tissue injuries caused in major surgical procedures, often become immunosuppressive. To start to understand how the TCR network causes this, Yin's group collaborated with co-author Michael Yaffe, M.D., Ph.D., who is the David H.
Antibodies Antibody Biotechnology Blood Cancer Cell Cell Development Children Cytometer Cytometry DNA Flow Cytometry Fluorescence Fluorescence Microscopy Hospital Imaging Intracellular Kidney Kidney Disease Medical School Microscopy Nanotechnology Ph Polycystic Kidney Disease Research T-Cell Technology Transcription Transcription Factors
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