Acid produced during digestion helps explain why cancer worsens with age.
These friendly whales gave their own version of a synchronized swimming show, ‘waving’ to onlookers off the coast of New South Wales, Australia.
That culprit is methylmalonic acid , a byproduct of protein and fat digestion that is elevated in the blood of older people. Apublished Wednesday in the journal Nature reports that MMA can induce aggressive metastasis and drug resistance in cancer cells, both in the test tube and in mice. When the researchers analyzed the serum used to treat the cancer cells, they found that MMA was elevated in all of the samples that were able to induce metastasis. And when cancer cells were exposed just to elevated levels of MMA, the same changes were seen -- including the ability to induce new tumors in mice.
It is not yet clear how exactly all this works, but Blenis said it raises interesting new questions about how aging interacts with cancer, as well as potential new ways to prevent or treat it. The metabolic pathway that leads to MMA, for example, is known to be associated with certain fatty acids, so there could be implications for how diet affects cancer risk.
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