A study examining 1031 hospitalized COVID-19 patients found that aging significantly impacts immune responses, viral dynamics, and the nasal microbiome, with older adults experiencing more severe disease symptoms and delayed viral clearance.
By Vijay Kumar MalesuApr 18 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the journal Science Translational Medicine , researchers investigated the impact of aging on immune response, viral dynamics, and nasal microbiome in 1031 hospitalized coronavirus disease 2019 patients, using advanced profiling techniques to understand age-related differences in disease severity and immune function.
Background Age is a significant risk factor for severe COVID-19 outcomes, with older adults facing drastically higher risks of complications and mortality than younger individuals. Despite high vaccination rates, older adults are still profoundly vulnerable. Aging correlates with elevated levels of inflammatory cytokines, like interleukin-6 , which are critical markers of COVID-19 severity, hinting at a link between aging and disease pathophysiology.
Statistical analysis was performed using R software. Initial assessments were done within 72 hours of hospital admission, followed by longitudinal evaluations at subsequent visits. Data analysis applied various statistical methods depending on the data type and required adjustments for factors like age, sex, and baseline disease severity.
Related StoriesAt the initial hospital visit, typically within 72 hours of admission, a range of diagnostic assays was conducted. These included transcriptional profiling of peripheral blood mononuclear cells and nasal swabs, serum inflammatory protein profiling, whole blood mass cytometry , nasal metatranscriptomics, and SARS-CoV-2 antibody assays.
Covid-19 Immune Response Virus Antibody Blood Cell Coronavirus Cytokines Gene Hospital Interferon Interleukin Interleukin-6 Medicine Microbiome Monocyte Mortality Pathophysiology Respiratory SARS SARS-Cov-2
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