Taking hormone replacement therapy close to the start of menopause may be OK, but starting HRT too late may raise the risk of Alzheimer's disease later in life, a new study has suggested
Alzheimer’s disease strikes women harder than men — over two-thirds of those who descend into dementia’s devastating twilight are female at birth. That’s likely due to biological reasons that remain poorly understood, according to the Alzheimer’s Association. One key piece of the enigma: Women lose sexual hormones such as estrogen when they undergo menopause, either naturally through the body’s decreased production or by removal of the ovaries via surgery.
Hormone replacement therapy has been a loaded topic for many women since early, misguided results were published in 2002 from a study called the Women’s Health Initiative clinical trial. That preliminary analysis found an estrogen and progestin combo — the type of HRT prescribed at the time — increased the risk of heart disease as well as stroke, blood clots, dementia and breast cancer. The study was halted early due to the dangers. Fallout was dramatic.
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