Scientists have found evidence in mice and human brain tissue that the drug ponesimod can reduce inflammation and toxic amyloid plaques common in Alzheimer's.
The research was conducted by scientists from the University of Kentucky. They theorized that a particular receptor found in brain cells called microglia might play a role in Alzheimer’s and possibly other neurodegenerative diseases.Among their many functions, microglia help regulate the brain’s immune response and clear out toxic waste. One of these toxins is an abnormal form of the protein amyloid beta.
The team’s earlier work has suggested that abnormal amyloid beta might negatively influence microglia cells through a receptor called sphingosine-1-phosphate transporter spinster 2, or Spns2. So they wanted to see if they could block the process by using a drug already known to inhibit this receptor, theThey experimented with mice bred to develop Alzheimer-like illness as well as with human samples of microglia cells. In both cases, the ponesimod appeared to work as hoped.
simod performed better on memory tests than controls, indicating that the drug could potentially slow or stop Alzheimer’s symptoms. “The clearance of those proteins is an important target for Alzheimer’s disease therapy,” said lead author Zhihui Zhu in a from the university. “In our study, we reprogrammed microglia into neuron-protective cells that clean up toxic proteins in the brain, reduce Alzheimer’s neuroinflammatory pathology, and improve memory in the mouse model.”Of course, mice and lab experiments are only the starting point for showing that a treatment could do the same in human patients. Sincestudying its use in Alzheimer’s disease.
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