'This new drug could be especially important in a moment where depression is on the rise due to the global pandemic.'
For some people with clinical depression, oral antidepressants and talk therapy just don’t work. Those suffering from treatment-resistant depression might find benefit from a nasal spray that the Food and Drug Administration approved in March. The drug, esketamine , is a fast-acting version of the anesthetic ketamine.
Like all drugs, esketamine has the potential for abuse, so the FDA requires that the drug be administered to patients in a doctor’s office or clinic. It’s taken twice a week for four weeks along with oral antidepressants. And since esketamine can cause sedation, difficulty concentrating, and suicidal thoughts and behaviors, patients have to be monitored for two hours after taking the drug.
This new drug could be especially important in a moment where depression is on the rise due to the global pandemic. Although the effect of the virus on suicide rates is tricky to measure right now, Census Bureau data from this year shows that a third of Americans are showing signs of clinical anxiety and depression. On one question about depressed mood, the percentage of people indicating mood changes was double than in a 2014 study.
Although research on the drug is still being conducted, “the availability of a medicine that can begin providing relief within a day is potentially life-changing,” says Theresa Nguyen, chief program officer for Mental Health America. For people who have found no effective treatment for their depression, this new drug could possibly be a source of relief and consolation.
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