Improving antibiotic therapy decisions in newborns NatureComms jamanetworkopen
We included all neonates born alive at a gestational age of 34 weeks or later between January 1, 2014, and December 31, 2018, and treated for any reason with intravenous antibiotics started within the first postnatal week. There were no exclusion criteria. We recorded the total number of births and neonatal deaths and collected data on network characteristics and guidelines to prevent EOS and manage newborns at risk of EOS .
EOS was defined as culture-proven EOS, by positive blood and/or cerebrospinal fluid culture, within the first postnatal week. Contaminated blood or CSF cultures were defined by growth of bacteria usually considered as contaminants or cultures considered as a contamination by clinicians with a decision to treat with antibiotics for less than 5 days. Cultures with growth of coagulase-negative staphylococci and antibiotic therapy for more than 5 days were considered proven infection. Neonates without proven EOS were those who received antibiotics but did not have a diagnosis of EOS.
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