Chat GPT, a relatively unknown therapy for HFpEF, and two fun studies on statins and secondary prevention are the topics drjohnm, discusses in this week's podcast. CardioTwitter
Statins reduce cardiac outcomes by 25%. As I have said many times, these are heart attack reducing drugs.
Previous studies have suggested that vigorous or eccentric exercise may increase muscle damage markers, such as creatine kinase, more in statin users compared with statin nonusers. For this study, investigators recruited three groups:asymptomatic statin users; statin users who had SAMS; and controls. If you get low enough LDLs with lower intensity drugs, you might reduce side effects and improve adherence. On the other hand, treat-to-target involves more work .from South Korean investigators, first author Sung-Jin Hong. This is also a fun trial to discuss.One group is treated to a target LDL of 50 to 70 mg/dL. The other group received high-intensity statin therapy . Three-year follow-up with composite major adverse cardiac events as the primary outcome.
Here the investigators expected a 12% event rate for the composite of death, MI, stroke, or coronary revascularization. They set out an NI margin in absolute risk increase of 3%. So, if the upper bound of the risk of the risk difference was less than 3%, treat to target would be called NI to the simple just-use-high-intensity-statin strategy.
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