Are COVID Nasal Vaccines Our Ticket Out of the Pandemic?

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Are COVID Nasal Vaccines Our Ticket Out of the Pandemic?
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COVID nasal vaccines in the US may be in the near future. MucosalImmunity MedTwitter

The idea is gaining ground among infectious disease experts, and for good reason."The mucosal immune system and the circulatory immune system are separate," said Michael W. Russell, PhD, professor emeritus of microbiology and immunology at the University at Buffalo, New York, who has also written about thein fighting the pandemic."There is some cross talk, but they are largely independent.

The most robust immunity against COVID-19, according to Russell, comes when infection in the mouth and upper respiratory tract results in the secretion of immunoglobulin A antibodies, giving mucosal immunity. But, by following up that shot with a nasal vaccine, mucosal immunity at the entry point of the virus can be achieved.

"It's a single booster, so development will be fast," Musunuri said. It will be tested in those who already had a primary series of COVID vaccines.CoviLiv, a live-attenuated intranasal vaccine, performed well in a phase 1 study, according to J. Robert Coleman, PhD, cofounder and Chief Executive Officer of Codagenix, Farmingdale, New York.

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