A new study calls into question the clinical-trial results for Russia’s Sputnik V covid-19 vaccine. The Gamaleya institute, the developer of Sputnik V, disputes the study’s findings
are usually affected by all sorts of random circumstances, known as “noise” in the jargon. The implication is that, in this particular trial, the various sources of noise cancelled one another out in a way that generated a pattern of equivalent efficacy in all age groups.
For the four comparison vaccines, between a quarter and a half of the computed efficacies for all age subgroups fell within the range of their actual published efficacies. For Sputnik V none did. The researchers then repeated the exercise with 50,000 simulations per vaccine. For Sputnik V only 13 of those iterations fell in the reported ranges.
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