High level of heart attack protein linked to heightened risk of death from any cause
In our previous work, which included 20 000 consecutive patients most of whom had no indication for the test, we demonstrated that 1 in 20 patients had a cTnI concentration above the ULN and that this was associated with 1-year mortality across inpatients , outpatients and the emergency department .
The manufacturer-provided 99th percentile is 40 ng/L and this was used as the ULN in routine practice. The coefficient of variation at 40 ng/L is less than 10%, the limit of quantification is 20 ng/L, limit of detection 8 ng/L and the limit of blank is 5 ng/L. Serum was collected in serum separator tubes and stored at room temperature for up to 24 hours. CTnI concentrations were measured using the DxI800 platform .
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Triglycerides and risk of cardiovascular events in statin-treated patients with newly diagnosed type 2 diabetes: a Danish cohort study - Cardiovascular DiabetologyBackground Elevated triglyceride levels are a clinically useful marker of remnant cholesterol. It is unknown whether triglycerides are associated with residual cardiovascular risk in CVD-naïve patients with newly diagnosed type 2 diabetes mellitus (T2DM), who are already on statin therapy. We aimed to assess the association between triglyceride levels and risk of major cardiovascular events (MACE) in statin-treated patients with newly diagnosed T2DM managed in routine clinical care. Methods This cohort study included newly diagnosed T2DM patients without a previous diagnosis of cardiovascular disease in Northern Denmark during 2005–2017. Individual triglyceride levels while on statin treatment were assessed within 1 year after T2DM diagnosis. The primary outcome was a composite of myocardial infarction, ischemic stroke, or cardiac death (MACE). Patients were followed from one year after T2DM diagnosis until 30 April 2021, MACE, emigration, or death. We used Cox regression to compute hazard ratios (HRs) controlling for confounding factors. Results Among 27,080 statin-treated patients with T2DM (median age 63 years; 53% males), triglyceride levels were | 1.0 mmol/L in 17%, 1.0–1.9 mmol/L in 52%, 2.0–2.9 mmol/L in 20%, and ≥ 3.0 mmol/L in 11%. During follow-up, 1,957 incident MACE events occurred (11.0 per 1000 person-years). Compared with triglyceride levels | 1.0 mmol/L, confounder-adjusted HRs for incident MACE were 1.14 (95% CI 1.00–1.29) for levels between 1.0 and 1.9 mmol/L, 1.30 (95% CI 1.12–1.51) for levels between 2.0 and 2.9 mmol/L, and 1.44 (95% CI 1.20–1.73) for levels ≥ 3.0 mmol/L. This association was primarily driven by higher rates of myocardial infarction and cardiac death and attenuated only slightly after additional adjustment for LDL cholesterol. Spline analyses confirmed a linearly increasing risk of MACE with higher triglyceride levels. Stratified analyses showed that the associations between triglyceride levels and MACE were stronger among women.
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Takeaway pints from pubs banned from next month as COVID rules expireThe British Beer and Pub Association criticises the government's refusal to extend measures which were first introduced during the COVID pandemic to try to help struggling pubs.
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Senior doctors in England announce fresh strike dates if Government refuses deal on pay🔴 Consultant doctors in England have revealed they will strike on 19 and 20 September if the Government continues to “refuse to agree to pay talks” and present the profession with a credible offer
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Senior NHS doctors to strike for two more days next month in bitter row over payNHS consultants will go on strike again in September, the British Medical Association says. The top doctors have announced a third walkout to follow their next one at the end of this month. They wi…
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