Risk-stratified timing of birth at term may reduce a mother's risk of preeclampsia by half, analysis of a large UK cohort suggests.
Risk-stratified timing of birth at term may reduce a mother's risk of preeclampsia by half, analysis of a large UK cohort suggests.In this observational analysis of nearly 90,000 pregnancies, at-term preeclampsia occurred with similar frequency among women routinely screened during the first trimester and among at-risk women screened during the third trimester.
Although not currently recommended to prevent at-term preeclampsia,"timed birth by labor induction is a very common timing of birth strategy," she noted."At least one third of women currently undergo labor induction at term gestational age, and 1 in 6 choose to deliver by elective cesarean."The investigators analyzed data from a nonintervention cohort study of singleton pregnancies delivering at ≥ 24 weeks, without major anomalies, at two UK hospitals.
At 35-36 weeks, in a different cohort, 29,035 pregnancies were screened and term preeclampsia developed in 619 women. Demographics and pregnancy characteristics were similar to those screened at 11-13 weeks, although the average BMI was higher — in the overweight range — and there were fewer Black women, although they still made up 10% of the screened population.
The investigators found that overall, the proportion of term preeclampsia prevented was highest, and number-needed-to-deliver lowest, for preeclampsia screening at 35-36 weeks rather than at 11-13 weeks.
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