Researchers report promising results in early safety trials of convalescent plasma therapy, in which the blood of COVID-19 survivors is used to treat patients.
Scientists racing to stave off a tidal wave of coronavirus infections show renewed interest in a little-known medicine: convalescent plasma.While still considered experimental for COVID-19, the approach has proved effective in battling infectious diseases for more than a century. Convalescent plasma has rescued patients afflicted with diphtheria, smallpox and polio, as well as.
In the first of dozens of U.S. trials of convalescent plasma planned, researchers set out to ensure that the sickest COVID-19 patients who got the treatment were no more likely to die than similar patients who did not get it. To date, roughly 11,000 Americans have received experimental transfusions of convalescent plasma under a special wavier from the Food and Drug Administration. The new findings are based on the first 5,000 of those patients, all of whom had severe or life-threatening COVID-19 or were at risk of developing it.
Joyner and his colleagues recorded and tallied all “adverse events” — everything from a case of hives to death — that followed a transfusion of between 200 and 400 milliliters of plasma.In the four hours after receiving a transfusion, fewer than 1% suffered a serious adverse event, including decreased oxygenation, fluid buildup in the lungs or a severe allergic reaction. Any of those outcomes might be attributed to known complications of the plasma transfusion.
Overall, 15 of the 5,000 died within four hours of their transfusions. Three of those deaths were judged as possibly related to the transfusion, and a fourth was judged to be “probably” related.
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