Blood test may aid early detection of Parkinson's and guide treatment strategies

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Blood test may aid early detection of Parkinson's and guide treatment strategies
Blood TestDiagnosticsParkinson's Disease
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To date Parkinson's disease (PD) is diagnosed clinically and rather late in the course of the disease. There is an urgent need to find an objective, quantifiable biomarker for the diagnosis of this highly prevalent movement disorder.

IOS PressJul 23 2024 To date Parkinson's disease is diagnosed clinically and rather late in the course of the disease. There is an urgent need to find an objective, quantifiable biomarker for the diagnosis of this highly prevalent movement disorder . Research ers have now found initial evidence that a blood test to detect the alpha-synuclein protein is a viable, less invasive option to diagnose PD.

In a previous publication this research team was able to show that alpha-synuclein can also be detected in the blood of PD patients by isolating small vesicles from neuronal cells from the blood and amplifying the alpha-synuclein they contain using a seed amplification assay . Researchers analyzed cross-sectional blood samples from PD patients and compared these to samples of age- and gender-matched healthy controls using a blood-based SAA. In this study, 79 of 80 PD patients showed a positive seeding of alpha-synuclein derived from blood, while none of the healthy controls showed a positive blood test. This confirms that the alpha-synuclein blood marker is highly sensitive for PD.

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Blood Test Diagnostics Parkinson's Disease Protein Biomarker Movement Disorder Research

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