Science, Space and Technology News 2023
Recent research offers fresh insights into the causes of SUDEP . The study pinpointed a specific region in the amygdala that, when stimulated, can induce prolonged apnea, even after a seizure concludes. This groundbreaking discovery, combined with innovative brain imaging techniques, may lead to enhanced understanding and potential preventive treatments for SUDEP.
“This is the first study to identify a site in the brain that can cause persistent apnea after the seizure ends,” says Brian Dlouhy, MD, UI associate professor of neurosurgery and pediatrics, and senior author on the new study published online on Octoctober 3 in. “We think this closely resembles the apnea that occurs and has been monitored in SUDEP cases reported in the literature, suggesting that this focal area of the amygdala underlies persistent apnea that can lead to death.
The study suggests that not every patient is at risk for this phenomenon; only five of the patients developed prolonged apnea following amygdala stimulation. In addition, the exact location within the amygdala was also important. Even within the same patient, stimulating one part of the amygdala caused only temporary loss of breathing while stimulating a different area led to persistent apnea after the stimulation stopped.
“This novel technique allows us to look at causal effects from stimulating one site in the brain to see what else it is doing at other sites. It allows us to look at circuitry,” he adds.
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