To transcribe the information contained in our genes or to repair the dozens of breaks that occur daily in our DNA, our enzymes must be able to directly access the DNA to perform their functions.
Lawrence Berkeley National Laboratory Aug 9 2024 However, in the cell nucleus , this access is limited because the DNA strands are often tightly coiled and packed around proteins like threads around spools.
Eva Nogales, senior faculty scientist at Berkeley Lab, UC Berkeley professor, and Howard Hughes Medical Institute investigator To shed light on the structure of TIP60, Nogales and her team at Berkeley Lab and UC Berkeley purified and studied samples prepared by the Côté group. "Professor Nogales not only has access to the specialized equipment required to perform this type of analysis, but her expertise in high-resolution cryo-electron microscopy is recognized worldwide," he said.
Côté said that a good understanding of the structure of TIP60 is essential if we hope to develop new targeted therapies for diseases associated with low levels of TIP60, including Alzheimer's.
Cancer Cell Cell Nucleus Electron Electron Microscopy Genes Laboratory Microscopy Protein Research
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