There is a tie between generic antidepressant fluvoxamine and a reduced risk of COVID-19 hospitalizations, according to the latest findings from a review of three rigorous clinical trials.
A generic antidepressant may be able to keep COVID-19 patients out of the hospital, though it’s unclear whether the cheap and readily available pill will be made part of the pandemic medicine cabinet.
“Fluvoxamine is an immediately available, safe, and inexpensive management option with a high probability of moderate efficacy,” the researchers concluded. Infectious disease physicians like del Rio are paying close attention to fluvoxamine, though some remain cautious about overstating the potential benefits of a drug three years into a pandemic beset by misinformation and sometimes lacking clinical data about COVID-19 vaccines and medications.
“The problem is other medicines like fluvoxamine actually have good data,” said Dr. David Boulware, an infectious disease doctor at the University of Minnesota Medical School who’s running a study evaluating several generic drugs including fluvoxamine and ivermectin as COVID-19 treatments. Late last year, a group of clinicians including Boulware requested that the FDA authorize fluvoxamine as a COVID-19 treatment.
The Institute for Clinical and Economic Review, a watchdog organization that studies the cost-effectiveness of drugs, earlier this year included fluvoxamine in a recent review of COVID-19 treatments. It ranked fluvoxamine of equal benefit to Lagevrio, Merck & Co. Inc.’s MRK, +1.00% authorized COVID-19 antiviral.
Also authorized for COVID-19 are existing therapies like the steroid dexamethasone, which helps severely ill COVID-19 patients, and Roche Holding AG’s ROG, -1.21% rheumatoid arthritis drug, Actemra.Hospitals and clinics in the U.S. are split on whether to prescribe fluvoxamine to COVID-19 patients right now. Barnes-Jewish Hospital in St. Louis prescribes it, as does Johns Hopkins Medicine, which added fluvoxamine to its COVID-19 treatment recommendations in November.
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