A type of drug developed for treating cancer holds promise as a new treatment for neurodegenerative diseases such as Alzheimer's, according to a recent study by researchers at Penn State, Stanford University and an international team of collaborators.
Penn StateAug 22 2024 A type of drug developed for treating cancer holds promise as a new treatment for neurodegenerative diseases such as Alzheimer's, according to a recent study by researchers at Penn State, Stanford University and an international team of collaborators.
Alzheimer's disease is the most common type of dementia, an umbrella term that refers to all age-associated neurodegenerative disorders, McReynolds explained. In 2023, as many as 6.7 million Americans were living with Alzheimer's disease, according to the Centers for Disease Control and Prevention, and its prevalence is expected to triple by 2060.
"Scientists have been targeting the downstream effects of what we identify as an issue with the way the brain powers itself," said Praveena Prasad, doctoral student at Penn State and co-author on the paper. "The therapies that are currently available are working to remove peptides that are likely the result of a bigger issue we can target before those peptides can start forming plaques.
The researchers conducted the study in several models of Alzheimer's pathology, namely amyloid or tau accumulation and found that the protective effects of blocking IDO1 cut across these two different pathologies.
Aging Alzheimer's Disease Biochemistry Brain Breast Cancer Chronic Dementia Enzyme Glucose Glucose Metabolism In Vitro Leukemia Medicine Melanoma Metabolism Molecular Biology Neurodegeneration Neurodegenerative Diseases Neurons Pathology Peptides Research
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