How incarceration raises risk of cancer and death, even after release yale PLOSONE
To our knowledge, national studies of the relation between incarceration and cancer prevalence and stage at diagnosis have not been conducted, resulting in an important knowledge gap regarding cancer disparities in the USA.We used 10 years of data from the National Survey on Drug Use and Health to examine differences in cancer prevalence among individuals with and without prior criminal justice involvement.
Table 1 Adjusted Cancer Prevalence per 1000 Individuals by Past Year Criminal Justice Involvement StatusWe present the most recent estimates of cancer prevalence in Americans with a history of criminal justice involvement. This is the first national study to identify an increased prevalence of lung cancer and alcohol-related cancers in those with criminal justice involvement.
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Identification of biomarkers related to copper metabolism in patients with pulmonary arterial hypertension - BMC Pulmonary MedicineBackground The pathogenesis of pulmonary arterial hypertension (PAH) and associated biomarkers remain to be studied. Copper metabolism is an emerging metabolic research direction in many diseases, but its role in PAH is still unclear. Methods PAH-related datasets were downloaded from the Gene Expression Omnibus database, and 2067 copper metabolism-related genes (CMGs) were obtained from the GeneCards database. Differential expression analysis and the Venn algorithm were used to acquire the differentially expressed CMGs (DE-CMGs). DE-CMGs were then used for the coexpression network construction to screen candidate key genes associated with PAH. Furthermore, the predictive performance of the model was verified by receiver operating characteristic (ROC) analysis, and genes with area under the curve (AUC) values greater than 0.8 were selected as diagnostic genes. Then support vector machine, least absolute shrinkage and selection operator regression, and Venn diagrams were applied to detect biomarkers. Moreover, gene set enrichment analysis was performed to explore the function of the biomarkers, and immune-related analyses were utilized to study the infiltration of immune cells. The drug-gene interaction database was used to predict potential therapeutic drugs for PAH using the biomarkers. Biomarkers expression in clinical samples was verified by real-time quantitative PCR. Results Four biomarkers (DDIT3, NFKBIA, OSM, and PTGER4) were screened. The ROC analysis showed that the 4 biomarkers performed well (AUCs | 0.7). The high expression groups for the 4 biomarkers were enriched in protein activity-related pathways including protein export, spliceosome and proteasome. Furthermore, 8 immune cell types were significantly different between the two groups, including naive B cells, memory B cells, and resting memory CD4 T cells. Afterward, a gene-drug network was constructed. This network illustrated that STREPTOZOCIN, IBUPROFEN, and CELECOXIB were shared by the PTGER4 and
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Diagnostic classification of childhood cancer using multiscale transcriptomics - Nature MedicineA new multilevel clustering approach applied retrospectively to 13,000 transcriptomes of different tumors reveals a new diagnostic classification of childhood cancers, in some cases allowing a better prediction of disease outcomes.
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Developing postoperative delirium associated with a faster rate of cognitive decline, says studyResearch published today (March 20) in the JAMA Internal Medicine finds that developing postoperative delirium is associated with a 40% faster rate of cognitive decline over those who do not develop delirium.
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Green tea holds potential as treatment for uterine fibroids, PCOS, and menopausal symptomsGreen tea holds potential as treatment for uterine fibroids, PCOS, and menopausal symptoms greentea endometriosis EGCG fibroids adenomyosis dysmenorrhea; infertility PCOS menopause Nutrients_MDPI HopkinsMedicine
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OPEC Secretary General Calls For Coordination Between Oil Exporting Countries | OilPrice.comOPEC’s Secretary General has called for coordination between oil producers globally in order to reduce volatility in the oil market.
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Nine-time Grammy winner Norah Jones coming to BelfastGeneral sale tickets will be available from Friday, March 24
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