Using AI to predict an important measure of heart performance JAMACardio
Can deep neural networks predict left ventricular ejection fraction from angiograms compared with transthoracic echocardiogram –measured LVEF?In this cross-sectional study of 4042 adult angiograms matched with corresponding TTEs from 3679 UCSF patients, a DNN was trained to estimate reduced LVEF and continuous LVEF. The DNN showed good discrimination in internal and external validation data sets.
This was a cross-sectional study with external validation using patient data from December 12, 2012, to December 31, 2019, from the University of California, San Francisco . Data were randomly split into training, development, and test data sets. External validation data were obtained from the University of Ottawa Heart Institute.
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Oxygen therapy found to improve heart function in patients with long COVIDA small randomized trial in patients with post-COVID syndrome has found that hyperbaric oxygen therapy promotes restoration of the heart's ability to contract properly. The research is presented at EACVI 2023, a scientific congress of the European Society of Cardiology (ESC).
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Diabetes drugs associated with fewer adverse cardiac events in older veteransGLP1 receptor agonists—a class of diabetes medications—are associated with fewer major adverse cardiovascular events than another type of diabetes drug (DPP4 inhibitors) in older veterans with no prior heart disease. The findings, reported in Annals of Internal Medicine, will aid clinicians in choosing a diabetes drug regimen for older patients.
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School warning as pupil has 'cardiac episode after drinking Prime'Milton Primary School sent out a warning to other parents after the incident.
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A fixed reconstruction of fully edentulous patients with immediate function using an apically tapered implant design: a retrospective clinical study - International Journal of Implant DentistryBackground Immediate function has become an accepted treatment modality for fixed restorations in completely edentulous jaws. It is known that implant microtopography (surface) may enhance osseointegration, while implant macrotopography (macrodesign) plays an important role in primary stability in the patient requiring an immediate loading. The aim of this retrospective study was to evaluate the clinical and radiographic outcomes of the edentulous subjects treated with narrow and/or regular diameter, which placed and loaded immediately. Methods Forty-two consecutive patients received 171 implants, including regular and narrow diameter implants (NDIs). Each jaw, 19 mandibles and 24 maxillae, was treated with a fixed-full arch prosthesis according to the Straumann® Pro Arch concept. The majority (95%) of the restorations were supported by four implants, of which the posterior two implants were tilted. A provisional functional acrylic prosthesis was delivered on the day of surgery. All patients were followed up to 55 months. Cumulative survival rate was determined using Kaplan-Meier analysis. Radiological measurement of marginal bone level was performed. Results The overall follow-up time for survival rate was up to 55 months. Four implants (3 implants in maxilla, 1 implant in mandible) were lost, resulting in an overall cumulative implant survival rate of 97.7%. Implant survival rate in the axial and tilted implants was not statistically significant. The mean of interproximal marginal bone loss was 0.15 mm after 24 months. Good soft tissue health was observed in almost 99% of patients. The final prosthesis survival rate was 100%. Conclusions The results of this retrospective pilot study indicated that total edentulous patients requiring an immediate implant placement and loading can be successfully treated with this implant design. The improved mechanical properties of these implants might give a more conservative treatment option for the jaws showing a severe horizon
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Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patientsAuthor summary Retrospective studies have shown that COVID-19 patients taking HMGCR-inhibiting statins exhibit a reduced risk of mortality. However, potential variability in statin effects has been detected and studies from diverse sub-fields also suggest that this seemingly homogeneous class of compounds may function differently despite close chemical similarity. Based on predictions of a computational drug repurposing algorithm in combination with clinical evidence gathered during the COVID-19 pandemic, we identified that different statin types appear to have different biological properties despite similar chemical structure and they vary in their association with increased survival in COVID-19 patients. Together, in silico predictions from patient transcriptomics data, in vitro assays of infection, cytotoxicity, and host response, and retrospective clinical data provide a more comprehensive assessment of individual statin activity. Our findings, along with other emerging data, suggest that some statins (i.e., simvastatin, atorvastatin, and rosuvastatin), but not others, have a mitigating effect on the severity of COVID-19 disease reflected in a reduction in mortality. Importantly, different statins seem to exert different biological activities despite similar chemical structure and shared known mechanism of action related to lipid metabolism. These findings suggest that drug repurposing efforts may require consideration of drug-specific effects rather than accepted mechanisms.
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Sleep as a vital sign - Sleep Science and PracticeSleep is causally linked to the maintenance of every major physiological body system and disturbed sleep contributes to myriad diseases. The problem is, however, is that patients do not consistently, nor spontaneously, report sleep problems to their clinicians. Compounding the problem, there is no standard-of-care approach to even the most rudimentary of sleep queries. As a result, sleep disturbances remain largely invisible to most clinicians, and consequentially, unaddressed for the patient themselves – thereby exacerbating physical and mental health challenges due to unaddressed sleep problems. In this review, we argue that all patients should be routinely screened with a short, readily available, and validated assessment for sleep disturbances in clinical encounters. If the initial assessment is positive for any subjective sleep-related problems, it should prompt a more thorough investigation for specific sleep disorders. We further describe how a program of short and simple sleep health screening is a viable, efficacious yet currently missing pathway through which clinicians can 1) screen for sleep-related problems, 2) identify patients with sleep disorders, 3) rapidly offer evidence-based treatment, and (if indicated) 4) refer patients with complex presentations to sleep medicine specialists.
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