Carotenoids' potential in reducing chronic disease risk Nutrients_MDPI intestinal microbiota metabolites absorption
By Bhavana KunkalikarMay 15 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal Nutrients, researchers explore the association between the gastrointestinal delivery system and carotenoids.
About the study The authors of the current study conducted a search for research articles on the interaction between carotenoids and intestinal microbiota using the keywords “gut microbiota," "carotenoids," and "interaction" on PubMed and Science Direct. The article abstracts were analyzed and categorized into two groups including carotenoids' impact on human health and their interaction with gut microbiota.
Carotenoids were found to be metabolized during the fermentation of colonic fecal samples in one recent study, which resulted in the creation of new compounds. This suggests that the intestinal microbiota plays a role in the generation of these compounds. Related StoriesCarotenoids not only have a scavenging function but are also believed to have an indirect action that may involve interactions with cellular signaling cascades, including mitogen-activated protein kinase , nuclear factor erythroid 2–related factor 2 , and nuclear factor κB . Carotenoids have been found to regulate NF-κB by interacting with NF-κB subunits and IκB kinase , which inactivates the NF-κB pathway and reduces the transcription of pro-inflammatory cytokine genes.
As a result, these metabolites have some biological effects. Some microbes in the colon produce carotenoids, which have a prebiotic-like effect and can cause beneficial bacterial changes associated with improved health.
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