Before a cell commits fully to the process of dividing itself into two new cells, it may ensure the appropriateness of its commitment by staying for many hours-;sometimes more than a day-;in a reversible intermediate state, according to a discovery by researchers at Weill Cornell Medicine.
Weill Cornell Medicine Jun 27 2024 Their revelation of this fundamental feature of biology includes details of its mechanisms and dynamics, which may inform the development of future therapies targeting cancers and other diseases.
Although the role of this pre-commitment state of cell division is not yet entirely clear, it appears to be a safety mechanism to avoid inappropriate cell division, and may also activate DNA-repair functions. In any case, it appears to be a basic-;and until now undiscovered-;aspect of cell biology, with likely implications for understanding cancer, wound healing, and other cell division-related processes.
Cell division is the basic process underlying the growth and development of living things, and even in adult organisms is necessary for the repair of wounds and the general maintenance of tissues. While it has been known that the division process starts in a cell when various input signals trigger the activation of E2F, how this works has always been something of a mystery.
"It became clear that cells can stall in this primed state for more than a day before returning to quiescence or advancing to cell division," Dr. Konagaya said.
Cell Division Cancer DNA DNA Damage Mammalian Cells Medicine Protein Transcription
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