Significant changes in the gut microbiota occur in the earliest stages of Parkinson's disease, and a new study shows these can start before the onset of symptoms.
."In addition, a prodromal stage of RBD has been increasingly recognized, underscoring the importance of studying gut microbiota at an even earlier prodromal stage."found some of the features of RBD in close family members of RBD patients, along with digestive issues, suggesting that these individuals could be harboring gut bacteria changes. So scientists considered whether these relatives could be key to investigating the extremely early stages of Parkinson's disease.
To find out, the researchers behind this latest investigation analyzed stool samples from 441 people in Hong Kong. They included people with RBD, or a family history of the disease, people who had Parkinson's disease with motor symptoms for less than 5 years, and healthy people for comparison. They found 84 families and 249 genera of bacteria and compared the diversity of bacteria present between the four different groups of people.
The analysis controlled for factors that could affect the results; functional constipation was more common in early Parkinson's disease patients than in those without the disease, as were certain medications. The composition of gut bacteria in the early Parkinson's disease group was significantly different from the control group. And the RBD group's bacterial composition was similar to the early Parkinson's disease group but different from the control and RBD relatives groups.
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