Childhoodobesity linked to increased risk of 4 of 5 newly proposed subtypes of adult-onset diabetes
]. Children with overweight/obesity often become obese adults, and adult obesity is most likely a mediator in the link between childhood obesity and adult-onset diabetes. This study is the first to investigate genetic correlations between childhood/adult adiposity and different diabetes subtypes. The weak genetic correlation between childhood obesity and adult diabetes indicates that the genes promoting childhood adiposity are largely distinct from those promoting diabetes during adulthood.
The strength of this study is the use of GWAS data for type 2 diabetes subtypes from the same study population and the unified method of GWAS analysis. This increases the comparability across diabetes subtypes and reveals potentially different mechanisms linking childhood adiposity to different subtypes. In addition, the calculation of genetic correlation with childhood/adult adiposity provides deeper insights into the genetic links between life course adiposity and diabetes subtypes.
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