Within two weeks of getting the vaccine, the immune systems of most who had received doses had developed a type of antibody that could attach to the virus.
A new study out of China suggests that it should be possible to develop a safe vaccine against COVID-19, though the effectiveness of a single shot remains unclear.Friday, Chinese researchers revealed that their candidate vaccine has so far been tested in 108 healthy adults ages 18 to 60 in Wuhan, China, where the pandemic began.
The key outstanding question is whether this vaccine or other similar ones can generate enough of these neutralizing antibodies to protect people against the virus, said Peter Jay Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine in Houston. Another option, Hotez said, will be to boost the effectiveness of this type of vaccine with a second type of vaccine.“It is exciting to see” that the vaccine triggered an immune response, said Bruce Walker, director of the Ragon Institute of MGH, MIT and Harvard, which studies the immune system and recently shifted its focus to COVID-19. “But the investigators are appropriately cautious about interpretation since we don’t know if these levels are what is needed for protection.
Older people are more likely to have been exposed to the Ad5 cold virus, simply because they’ve been alive longer, meaning the vaccine is least likely to work in the people who need it the most, Walker said via email.
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