Circadian disruption induces weight gain through changes in gut microbiota CircadianRhythm Diabetes Food Gastrointestinal Circadian GeneExpression Genetic Glucose Metabolism Microbiome Obesity MolMetab TU_Muenchen UniLuebeck UniOfSurrey
Study: Original Article Genetic and environmental circadian disruption induce weight gain through changes in the gut microbiome. Image Credit: Alpha Tauri 3D Graphics / Shutterstock
About the study In the present study, the researchers determined clock gene expression in various gastrointestinal tissues using quantitative real-time polymerase chain reaction in different mice models. Nuclear magnetic resonance measurements determined the fat, free fluid, and lean mass composition of the body. Tissue and blood samples from the sacrificed mice were then used to measure gut permeability, triglyceride, and plasma glucose levels. High-throughput sequencing of the 16S ribosomal ribonucleic acid and classification of enzymatic genes was conducted to determine microbiome composition and functionality.
In the Bmal1SCNfl/- mice, arrhythmicity of the microbiome was associated with adiposity, disruption of glucose homeostasis, and weight gain. Similarly, the SSW mice displayed an increase in body weight and plasma glucose levels associated with disrupting microbiome oscillation patterns.
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