Researchers investigate the potential link between the obesity drugs semaglutide and liraglutide and suicidal or self-injurious adverse drug reactions.
By Dr. Sushama R. Chaphalkar, PhD.Reviewed by Benedette Cuffari, M.Sc.Aug 26 2024 Study: Disproportionality Analysis From World Health Organization Data on Semaglutide , Liraglutide, and Suicidality. Image Credit: myskin / Shutterstock.com
Concerns about the safety of GLP-1 RAs, particularly the risk of suicidal ideation, have emerged. Although regulatory agencies including the European Medicines Agency and United States Food and Drug Administration have initiated investigations into these risks, no definitive relationship has been established between these drugs and suicide risk.
A comprehensive search of the database was conducted for reports related to these drugs that focused on ADRs classified under ‘suicide/self-injury.’ Semaglutide reports were collected between July 2011 and August 2023, whereas liraglutide reports were obtained between November 2000 and August 2023. Study findings A total of 36,172,078 reports were analyzed for the current study. The primary indication for prescribing both liraglutide and semaglutide was potential off-label use, followed by weight management and diabetes treatment. A total of 107 cases of self-injurious ADRs for semaglutide and 162 cases for liraglutide were identified.
Disproportionality analyses indicated significant signals for semaglutide-associated suicidal ideation with an ROR of 1.45 as compared to other medications. Sensitivity analyses confirmed this finding, particularly in cases involving comedications such as antidepressants and benzodiazepines, which are associated with an increased risk of suicidal behavior.
Semaglutide Diabetes Drugs Food GLP-1 Glucagon Glucagon-Like Peptide-1 Mental Health Obesity Receptor Type 2 Diabetes Weight Loss
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