Alvin Kamara and Jonathan Taylor have been two of the most successful and versatile running backs in the NFL
. On Sunday, they will be on opposite sidelines for the first time when the New Orleans Saints visit Indianapolis. Both missed the first part of the season, but seem to be rounding into midseason form. The Saints are trying to snap a two-game losing streak against a foe it has beaten four straight times. The Colts also have lost two straight since quarterback Gardner Minshew replaced injured rookie Anthony Richardson as the starter.OPENING LINE: Colts by 1 1/2, according to FanDuel Sportsbook.
KEY MATCHUP: Saints RB Alvin Kamara vs. Colts run defense. Like Taylor, the five-time Pro Bowler is ramping up his workload after missing the first three games. He's been limited to fewer than 70 yards in three times, is averaging 3.6 yards per carry each of the past three weeks and has averaged 4.2 yards on 104 total touches. The Colts, meanwhile, allow 118.7 yards rushing per game.
SERIES NOTES: The Saints have won four straight in the series, a streak that began with New Orleans' Super Bowl victory on Feb. 7, 2010. ... In three of the past six meetings, the winner has topped 40 points. The victory margin has been 27 points or more in four of those six. ... Yes, the Saints won their only game at Lucas Oil Stadium, 27-21 in 2015. It's not their only appearance in the facility.
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