Drug repurposing shows promise in the treatment of retinal degenerations, according to a new study by an international team of researchers, published in Nature Communications.
University of Eastern Finland Jul 22 2024 A combination treatment incorporating three existing drugs - tamsulosin, metoprolol and bromocriptine - slowed disease progression in pre-clinical retinopathy models.
A combination treatment incorporating three drugs slowed disease progression The researchers found that a combination treatment incorporating three drugs significantly slowed disease progression and decreased disease manifestation in four different animal models of IRD.
In retinal degenerations, intracellular secondary messengers such as cyclic adenosine monophosphate and calcium are believed to be overactive, exacerbating the disease. Metoprolol, tamsulosin and bromocriptine suppress the activity of these secondary messengers via their own distinct cell membrane-receptor actions.
Drugs Efficacy Retinal Degeneration Retinopathy
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