Roughly 1 percent of the general population is currently being treated with corticosteroids for diseases like COPD or asthma.
The study looked at data from the, a biomedical research center that followed half a million residents of the United Kingdom from 2006 to 2010. The researchers found 222 oral glucocorticoid users and 557 users of inhaled glucocorticoids who did not have a previous diagnosis of any neurological, hormonal, or mental health disorder.The team then performed cognitive and mental health testing on these 779 individuals and took diffusion MRIs of their brains.
“This study shows that both systemic and inhaled glucocorticoids are associated with an apparently widespread reduction in white matter integrity,” wrote study author Merel van der Meulen, a postdoctoral student at Leiden University Medical Center in the Netherlands. “The greatest amount of white matter damage was found in people who use oral steroids regularly over long periods of time, with inhalers having the smallest impact on brain matter.
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