This article outlines a detailed overview of the advancements and methodologies in CAR-NK cell therapy development.
Sponsored Content by Sino Biological Inc.Mar 14 2024Reviewed by Maria Osipova CAR-NK cell therapies are innovative therapeutic options developed for the purpose of overcoming some of the limitations associated with CAR-T cell therapies, such as therapy-induced side effects.CAR-NK cells display higher cytolytic activity than memory T cells and untransduced NK cells, making them more effective at killing tumor cells.
CAR-NK cell therapy is a groundbreaking type of cancer immunotherapy for solid tumors and hematological malignancies, which leverages the use of NK cells. Car development The CARs are able to identify and bind to targeted antigens on the surface of tumor cells. Therefore, ensuring CARs of the highest quality is a crucial part of CAR development. Sino Biological cutting-edge technologies have enabled the development of four CAR development platforms for single-chain variable fragment discovery.
Sino Biological offers top-class monoclonal antibody humanization services that can facilitate successful humanization with good results .Among all CAR structures, a key element of CAR functionality is how scFv binds to its target antigen. Sino Biological offers SPR/BLI assay services which can screen appropriate scFv molecules effectively, thus supporting CAR-NK development with full effect.
Efficient NK cell transduction starts with physiological NK cell activation to provoke cell growth. Despite the various methods available today which promote NK cell proliferation, the two most commonly used approaches are feeder cells and cytokine mixtures. Sino Biological’s years of experience in virus packaging has led to the development of an HEK293 serum-free medium, Sinofection® transfection reagent, and SuperNuclease. These products ensure high virus titer and transfection efficiency. Sino also offers cell bank testing services and SuperNuclease ELISA Kits to meet the various needs of CAR-NK and cell therapy researchers.