It causes the destabilization of the genome.
Looks pretty effective, right? Well, a new study says it may not be the case due to some downsides.researchers from Tel Aviv University warn that CRISPR may not always be safe since rearranging pieces of DNA jeopardizes genomic stability and could promote cancer in the long run.Developed about a decade ago, CRISPR is a groundbreaking technology that has won the 2020 Nobel Prize in Chemistry.
The novel study investigates the influence of this CRISPR on T-cells. It identifies the risks of the innovative technology, which has been employed to treat conditions like cancer, liver and intestinal diseases, and genetic syndromes. In the end, the researchers detected a loss of genetic material in a significant percentage, up to 10% of the treated cell. Such a loss may cause the destabilization of the genome, paving the way for cancer.
“Our intention in this study was to shed light on potential risks in using CRISPR therapeutics. We did this even though we are aware of the technology's substantial advantages," said Dr. Adi Barzel and his doctoral student Alessio Nahmad Therefore, the researchers caution that using CRISPR therapeutics requires extra attention.
. We have even established two companies - one using CRISPR and the other deliberately avoiding this technology. In other words, we advance this highly effective technology while at the same time cautioning against its potential dangers.
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