CRISPR/sgRNA-SAM therapy: a potential breakthrough for Parkinson's disease? GeneTherapy_SN CRISPR Parkinsons disease parkinsonsdisease
By Susha Cheriyedath, M.Sc.Aug 11 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in Gene Therapy, researchers utilize the CRISPR-Cas9 system to induce the synthesis of dopamine in the brains of a rat model for Parkinson’s disease .
The optimal approach for managing PD involves the use of levodopa , a precursor that facilitates the formation and substitution of DA. Importantly, this treatment has a finite duration of effectiveness, which typically spans about five years. The present study examines the effects of endogenous gene activation in stimulating DA production in astrocytes, followed by the implantation of these cells in a rat model of PD. These findings offer a targeted therapeutic approach that can increase the drug-free period of treatment and can be combined with other therapies in advanced cases of PD.
Related StoriesThe 6-hydroxydopamine lesion stereotaxic surgery is a widely used rat model to study PD. Herein, 6-OHDA is injected directly into the median forebrain bundle , wherein it destroys dopamine neurons. Control rats underwent the same procedure but were injected with a 0.1% ascorbic acid in saline solution.
Behavioral studies revealed that rats that received primary astrocytes exhibited significantly greater circling behavior as compared to rats that received AST-TH cells. Likewise, rats treated with control astrocytes exhibited significant differences in forelimb placement asymmetry in the cylinder test as compared to AST-TH transplanted rats.
Deutschland Neuesten Nachrichten, Deutschland Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Review examines visual disturbances among Parkinson’s disease patientsIn a recent review published in Brain Sciences, researchers reviewed existing data on visual impairments among Parkinson’s disease (PD) patients.
Weiterlesen »
Virgin Galactic launches space tourism flight - exact time and how to watchVirgin Galactic launches first space tourism flight - exact time, how to watch and who is on board
Weiterlesen »
Pensioner near Market Drayton with Parkinson's blasting into space today on Virgin Galactic flightAn 80-year-old man with Parkinson's is set to blast into space on a company's first tourist flight today.
Weiterlesen »
Josie Gibson confirms romance and is 'in love' with ITV co-star boyfriendJosie has confirmed her romance with This Morning cameraman Sam Morter.
Weiterlesen »
Sam Allardyce warns (hopes?) Newcastle United fans could turn on Eddie HoweAhead of the new season, Sam Allardyce warns (hopes?) Newcastle United fans could turn on Eddie Howe.
Weiterlesen »
Friends gather in Staffordshire to watch Olympian's space flightMembers of a Parkinson's support group watch Jon Goodwin blast off for the edge of space.
Weiterlesen »