Nature research paper: Crucial role and mechanism of transcription-coupled DNA repair in bacteria
. Here we combined in cellulo cross-linking mass spectrometry with structural, biochemical and genetic approaches to map the interactions within the TCR complex and to determine the actual sequence of events that leads to NER in vivo. We show that RNA polymerase serves as the primary sensor of DNA damage and acts as a platform for the recruitment of NER enzymes.
recruits a second UvrD monomer to form a helicase-competent UvrD dimer that promotes backtracking of the then recruits a second UvrA molecule and UvrB to initiate the repair process. Contrary to the conventional view, we show that TCR accounts for the vast majority of chromosomal repair events; that is, TCR thoroughly dominates over global genomic repair. We also show that TCR is largely independent of Mfd.
Deutschland Neuesten Nachrichten, Deutschland Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Matching drugs to DNA is 'new era of medicine'Testing can predict if drugs will work, fail or become deadly, depending on differences in our make-up.
Weiterlesen »
Save Over $100 On This Incredible Health-Focused DNA Test KitLearn what your body needs with this DNA test.
Weiterlesen »
To Learn More Quickly, Brain Cells Break Their DNADNA breakage may be a routine and important part of normal cellular processes—which has implications for how scientists think about aging and disease. Via QuantaMagazine
Weiterlesen »
Prebiotics: What are they and how can they benefit our health?Prebiotics help to feed the good bacteria in your gut – here’s how
Weiterlesen »
Care Workers Are Essential. It’s Time to Build a Caring Economy.When crises strike, we turn to our friends, families and sometimes even complete strangers to provide an extra set of caring and supporting hands. Care workers have always played an essential role in our communities, from assisting with child care to providing professional support to the elderly. Our government has a once in a generation opportunity to pass policies that would support fair pay and dignified work conditions for caregivers, investing in the essential caregiving economy.
Weiterlesen »
When young people spend time in nature, it benefits their wellbeing — and our environmentWhen young people spend time in nature, it benefits their wellbeing — and our environment [Opinion]
Weiterlesen »