Today is the 36th anniversary of the election of the first black MPs.
I follow directly in the footsteps of the former leader of Haringey Council and Tottenham MP, Bernie Grant, who entered the House of Commons in 1987.
Labour has paved the way for a diverse politics, and it is in that spirit that we have re-launched the. We need to improve black representation across all levels of elected office and be clear we’re acting on the Forde report, which made difficult reading for all of us proud of that history. It is with this in mind, and in reflecting on my own political journey into the Commons, that I am delighted to announce the launch of the Bernie Grant Programme. This programme is for any black Labour member who has the passion and ambitions to represent their community in political office for the Labour Party. Applications are open now.
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Mechanistic insights into the interactions between cancer drivers and the tumour immune microenvironment - Genome MedicineBackground The crosstalk between cancer and the tumour immune microenvironment (TIME) has attracted significant interest in the latest years because of its impact on cancer evolution and response to treatment. Despite this, cancer-specific tumour-TIME interactions and their mechanistic insights are still poorly understood. Methods Here, we compute the significant interactions occurring between cancer-specific genetic drivers and five anti- and pro-tumour TIME features in 32 cancer types using Lasso regularised ordinal regression. Focusing on head and neck squamous cancer (HNSC), we rebuild the functional networks linking specific TIME driver alterations to the TIME state they associate with. Results The 477 TIME drivers that we identify are multifunctional genes whose alterations are selected early in cancer evolution and recur across and within cancer types. Tumour suppressors and oncogenes have an opposite effect on the TIME and the overall anti-tumour TIME driver burden is predictive of response to immunotherapy. TIME driver alterations predict the immune profiles of HNSC molecular subtypes, and perturbations in keratinization, apoptosis and interferon signalling underpin specific driver-TIME interactions. Conclusions Overall, our study delivers a comprehensive resource of TIME drivers, gives mechanistic insights into their immune-regulatory role, and provides an additional framework for patient prioritisation to immunotherapy. The full list of TIME drivers and associated properties are available at http://www.network-cancer-genes.org .
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