A new study, 'Sensitive poliovirus detection using nested PCR and nanopore sequencing: a prospective validation study', published today (17 August 2023) in Nature Microbiology, proves that using DDNS to detect polio outbreaks can save public health authorities crucial time and money.
This research was jointly conducted by researchers at the Institut National de Recherche Biomédicale in Kinshasa who implemented DDNS in the Democratic Republic of the Congo for the detection of polio outbreaks in collaboration with the MHRA, Imperial College London, the University of Edinburgh and various laboratories of the World Health Organization Global Polio Laboratory Network , with support from the Bill and Melinda Gates Foundation.
Currently, stool samples from countries with active polio outbreaks such as the DRC must be shipped around the world for lengthy, complex laboratory tests to confirm a polio case. Faster detection of polio in the regions where outbreaks still occur allows for a faster response by authorities through targeted, localised vaccination campaigns, minimising the opportunity for the virus to spread. We are standing at a delicate and pivotal moment for the eradication of polio.
This research showed that DDNS tests done locally in the DRC over a six-month period were an average of 23 days faster than the standard method, with over 99% accuracy. This is the perfect example of collaboration, where combining and sharing knowledge together with all our partners has supported the vital work of the INRB in the DRC where poliomyelitis remains a serious public health problem.
As a consortium we look forward to the training of additional national laboratories in this method, with prior trainees, including members of INRB, now taking on the role of trainers. While many people may never show symptoms, in extreme cases, especially for babies and children under the age of five, polio can lead to permanent paralysis or death.
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