Scientists find more evidence that breastmilk of those vaccinated against COVID-19 may protect infants
To protect against SARS-CoV-2 infection, the immune system must mount a robust and specific response. In addition to SARS-CoV-2-specific antibody concentration, antibody specificity, affinity, and neutralizing capacity are also necessary to elicit a proper immune response. As such, we hypothesize that there is a transfer of neutralizing HM SARS-CoV-2 specific IgA and IgG to the intestinal tract of breast-fed infants that can protect them from COVID-19 infection.
Participants completed a questionnaire collecting maternal/infant demographics, medical and family history, and vaccination side effects upon agreeing to participate.Maternal blood samples were collected via venipuncture or finger prick in ethylenediaminetetraacetic acid-coated tubes at the designated time points. Plasma was separated from cellular matter by centrifugation at 2000 ×For milk, mothers were instructed to express samples of 10–30 ml.
To determine the neutralization capability of SARS-CoV-2 antibodies, we used an assay containing vesicular stomatitis virus expressing the SARS-CoV-2 Wuhan-hu-1 wild type strain spike protein and green fluorescent protein described in a previously published study []. Milk, plasma, or stool samples were mixed with VSV and later incubated with baby hamster kidney cells expressing human ACE2 receptors. GFP frequency was measured by flow cytometry to quantify BHK-ACE2 cell infectivity.
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