It’s tricky mapping non-human animal behaviors to our own. It’s even trickier linking those behaviors to changes in the brain.
— in the brains of deceased chimpanzees, our closest living relatives though the plaques and tangles in the chimp brains showed some slight molecular differences from those in humans. Amyloid beta was already known to be common in other non-human primates, such as rhesus monkeys and baboons, but tau tangles were not.
While old age is associated with some cognitive decline in all primates, “linking that to specific areas of the brain or specific changes in the brain,” he says, “has been a bit of a challenge.”, Walker and Swiss neuroscientist Mathias Jucker emphasize that non-human primates lack some of the abilities, such as language, that are key to diagnosing dementia in humans. In addition, a key element of dementia in humans is interference with the tasks of daily living.
So far, the lemurs have offered some hints that might be helpful to their human cousins. “We can definitely say that activity level and nutrition, both quantity and quality, play a role in cognitive decline in our lemurs,” says Pifferi. “In a few words: Too many calories are bad; too little activity is bad.”
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