Restoring the gut biome after antibiotics could lead to better outcomes for ovariancancer patients aacr
Epithelial ovarian cancer is the leading cause of gynecologic cancer death. Despite initial responses to intervention, up to 80% of patient tumors recur and require additional treatment. Retrospective clinical analysis of OC patients indicates antibiotic use during chemotherapy treatment is associated with poor overall survival. Here, we assessed whether antibiotic treatment would impact growth of EOC and sensitivity to cisplatin.
ABX treatment led to reduced apoptosis, increased DNA damage repair, and enhanced angiogenesis in cisplatin-treated tumors, and tumors from ABX-treated mice contained a higher frequency of cisplatin-augmented cancer stem cells than control mice. Stool analysis indicated non-resistant gut microbial species were disrupted by ABX treatment.
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