Measuring esophageal distensibility can help define the severity of early scarring in the esophagus of children with eosinophilic esophagitis, a new study indicates. PedsGI MedTwitter
/mmHg predicted grade 2 rings on endoscopy with area under the curve of 0.81 .
"Using the 16 cm EndoFLIP catheter, we found that a DI of < 3 was grade 2+ rings 90% of the time, and a DI of < 2 was grade 2+ rings 97% of the time," Wechsler saidThe DI provides"an objective measure of fibrostenotic severity in patients with EoE who are at least 9 years old without reliance on visual findings, which can be more subtle than in adults with dominant strictures," Wechsler added.
"Low distensibility has significant correlation with future food impactions, which is a clinical outcome that obviously has significant morbidity," Johnson told"Low distensibility is reflective of a submucosal scarring or fibrosis, which can be problematic, if not recognized, and endoscopic assessment doesn't always recognize all the areas of scarring, so this is a great way to localize and identify it upfront, and thereby, hopefully, get a much more directed intervention to...
To date, distensibility measurement has been used primarily in tertiary referral centers and in academic and investigational evaluations,"but it's not investigational," he noted. "Based on the growing evidence to support it, this should be in more widespread use and, in particular, for eosinophilicFunding for the study was provided by the Campaign Urging Research for Eosinophilic Diseases Foundation. Wechsler and Johnson report no relevant financial relationships.
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