DNA barcoding reveals cancercells' ability to evade the immune system NatureComms
being destroyed by the immune system, but leaving some undetected, which continue to grow and spread.tagged with a known DNA 'barcode', a sequence that was passed on from one generation of cells to the next.
"Lead author Dr. Simon Junankar wanted to understand whether resistance was adaptive—whether cancer cells duck and weave—or are they pre-programmed to evade the immune system," says Associate Professor Alex Swarbrick, a laboratory head and Co-Lead of the Dynamic Cellular Ecosystems in Cancer Program at Garvan.
The cells seem to do this with parallel approaches. One way is to suppress the action of killer T-cells, which would usually destroy harmful cells. The other is to reduce the expression of MHC1 on cells, which act as a flag for the immune system to recognize harmful cells.
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