The surprise discovery redirects liver disease treatment efforts. Researchers from the Walter and Eliza Hall Institute (WEHI) have demonstrated that common liver diseases are not caused by inflammatory cell death as was previously believed. This discovery settles a long-standing controversy in gast
For the first time, WEHI researchers have shown that a crucial subset of liver cells cannot undergo necroptosis, ruling out this kind of cell death as a cause of common liver diseases.Researchers from the Walter and Eliza Hall Institute have demonstrated that common liver diseases are not caused by inflammatory cell death as was previously believed. This discovery settles a long-standing controversy in gastroenterology and points to a new direction for treatment.
The surprise findings define the role and relevance of necroptosis in non-cancerous liver diseases, which affect billions of people worldwide Necroptosis has been regarded by researchers until now as being essential to the development of these diseases. It remained unclear, however, whether this kind of cell death was happening in liver cells or in immune cells that had entered the liver in response to infections or diet-related damage.
They found that deleting these genes had little effect, with disease progression proving comparable to normal hepatocytes. This revealed that necroptosis was not involved in the development of these liver pathologies.
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