While the liver is one of the body's most resilient organs, it is still vulnerable to the ravages of stress and aging, leading to disease, severe scarring and failure.
Duke University Medical CenterJun 26 2024 While the liver is one of the body's most resilient organs, it is still vulnerable to the ravages of stress and aging, leading to disease, severe scarring and failure. A Duke Health research team now might have found a way to turn back time and restore the liver.
Our study demonstrates that aging is at least partially reversible. You are never too old to get better." Studying the livers of mice, the researchers identified a genetic signature distinct to old livers. Compared to young livers, the old organs had an abundance of genes that were activated to cause degeneration of hepatocytes, the main functioning cells of the liver.
Importantly, key genes in the livers of people with MASLD were highly activated to promote cell death through ferroptosis. This gave the researchers a definitive target.Again turning to mice, the researchers fed young and old mice diets that caused them to develop MASLD. They then gave half the animals a placebo drug and the other half a drug called Ferrostatin-1, which inhibits the cell death pathway.
Diehl said the team also looked at how the ferroptosis process in the liver impacts the function of other organs, which are often damaged as MASLD progresses. The genetic signature was able to differentiate between diseased and healthy hearts, kidneys and pancreases, indicating that damaged livers amplify ferroptotic stress in other tissues.
Liver Stress Cell Cell Death Cholesterol Cirrhosis Diabetes Ferroptosis Genes Genetic High Cholesterol Liver Disease Medicine Obesity Research
Deutschland Neuesten Nachrichten, Deutschland Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Why Meghan Markle wouldn't have attended the Duke of Westminster's wedding with Prince HarryThe Duke of Sussex is a close friend of the Duke of Westminster
Weiterlesen »
The Duke of Westminster's grand home where multi-billionaire will live with bride Olivia HensonPrince William's friend will move to Cheshire upon marrying Olivia Henson
Weiterlesen »
The Duke of Westminster's bride Olivia Henson's wedding dress hintHugh Grosevenor's wife-to-be's bridal style explained
Weiterlesen »
The Duke of Westminster's socialite sisters' wildly different 'secret' weddings revealedHugh Grosvenor, the seventh Duke of Westminster, will tie the knot on Friday 8 June
Weiterlesen »
Duke of Westminster and Olivia Henson take inspiration from Princess Kate with church wedding flowersHugh Grosvenor and his wife-to-be Olivia are marrying on Friday
Weiterlesen »
Duke of Westminster and 'glowing' fiancée Olivia Henson attend pre-wedding rehearsal in ChesterThe bride and groom-to-be will tie the knot at Chester Cathedral
Weiterlesen »