Adopting pediatric readiness standards found to improve survival in hospital emergency departments nichd_nih jamanetworkopen
Is high emergency department pediatric readiness associated with lower short-term and long-term mortality among children?In this cohort study of 796 937 children cared for in 983 EDs, there was 60% to 76% lower odds of in-hospital death associated with care in high-readiness EDs; among a subset of 545 921 children followed up beyond hospitalization, the benefit of high-readiness EDs persisted to 1 year.
Participants included children younger than 18 years admitted, transferred to another hospital, or dying in the ED, stratified by injury vs medical conditions. Data analysis was performed from November 1, 2021, through June 30, 2022.ED pediatric readiness of the initial ED, measured through the weighted Pediatric Readiness Score from the 2013 National Pediatric Readiness Project assessment.
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Frontiers | Expression and clinical significance of short-chain fatty acids in pregnancy complicationsObjective: To investigate the expression of short-chain fatty acids (SCFAs)—metabolites of intestinal flora—in gestational complications of gestational diabetes mellitus (GDM), preeclampsia (PE), and intrahepatic cholestasis of pregnancy (ICP), and its clinical significance. Methods: Targeted metabonomics was used to detect SCFAs in the serum of 28 GDM pregnant women, 28 PE pregnant women, 29 ICP pregnant women, and 27 healthy pregnant women (NP); their expression changes were observed; the correlation between SCFAs and clinical characteristics was studied; and their potential as biomarkers for clinical diagnosis was evaluated. Results: There were significant differences in the SCFA metabolic spectrum between the GDM, PE, ICP, and NP groups. Quantitative analysis showed that the content of isobutyric acid in the three pregnancy complications groups (the GDM, PE, and ICP groups) was significantly higher than that in the NP group (p | 0.05), and other SCFAs also showed significant differences in the three pregnancy complications groups compared with the NP group (p | 0.05). Receiver operating characteristic (ROC) curve analysis of the generalized linear model showed that multiple SCFAs were highly sensitive and specific as diagnostic markers in the pregnancy complications groups, where isobutyric acid was highly predictive in GDM (area under the ROC curve (AUC)=0.764) and PE (AUC=1), and caproic acid was highly predictive in ICP (AUC=0.968), with potential clinical application. Conclusion: The metabolic products of intestinal flora, SCFAs, during pregnancy are closely related to pregnancy complications (GDM, PE, and ICP), and SCFAs can be used as potential markers of pregnancy complications.
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New long Covid study will provide hope for many who are still sufferingNew study conducted on over two million people in Israel finds most people who got long Covid after a mild case of coronavirus saw symptoms returning to normal within a year
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Most long COVID effects resolve within a year after mild infection, finds studyMost symptoms or conditions that develop after mild COVID-19 infection linger for several months but return to normal within a year, finds a large study from Israel published by The BMJ today.
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Wells Fargo: mortgage retreat long overdue\n\t\t\tLet our global subject matter experts broaden your perspective with timely insights and opinions you\n\t\t\tcan’t find anywhere else.\n\t\t
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Hope for millions with long Covid as study finds that symptoms should disappear within a yearAccording to the latest figures from the Office for National Statistics, an estimated 2.1 million people in private households in the UK were experiencing long Covid as of 4 December, 2022
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Long COVID symptoms 'resolve in a year' for most with mild illness, study findsAfter looking at the information of almost two million people, researchers in Israel found that mild symptoms of the virus will not lead to serious or chronic long-term health effects.
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