Scientists optimize methods to study brains at rest in a key model organism
. It was confirmed in a preliminary study that this dose enables prevention of spontaneous movement against sound and direct stimulation , but not against intubation to an endotracheal tube.A marmoset was restrained with leather gloves, and an in-dwelling needle was inserted into the tail vein. Subsequently, 0.25 mg/kg of Mida was administrated over 1 min for induction, and continuous rate infusion was performed at the rate of 0.6 mg/kg/h with a microsyringe pump.
After intratracheal intubation, the marmosets were connected to artificial ventilation for small animals , and mechanical ventilation was performed under the following conditions: 50% inspiratory oxygen, 8 mL of tidal volume, and 30 breaths per min RR. PR, SpO2, RR, EtCO2, inspiratory and end-tidal Iso concentrations, and rectal temperature were measured with a vital sign monitor.
In Awake condition, data were collected in the dark and monitored with an infrared camera to prevent the marmosets from falling asleep. If the marmosets were observed closing their eyes during a scan, they were awakened with a loud noise before the next scan was started. They were rewarded with a highly palatable food at the end of each imaging.
In sedate/anesthetic condition, the marmosets were monitored in the same way to observe spontaneous movement or coughing for intratracheal tube. If spontaneous movement or coughing was observed, additional sedatives/anesthetics were administrated and infusion rate or concentration of inhalational anesthesia was increased.An ultra-high field MRI system with a static magnetic field strength of 9.
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