Effectiveness of monovalent COVID-19 mRNA booster vaccination vs. two-dose primary series during Omicron variant circulation UWMadison mRNA COVID19 coronavirus covid Omicron virus pandmeic SARSCoV2 booster
By Pooja Toshniwal PahariaMar 7 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in Influenza and other respiratory viruses, researchers estimated the immune protection conferred by monovalent-type coronavirus disease 2019 messenger ribonucleic acid booster doses vs. two-dose prime vaccination series during severe acute respiratory syndrome coronavirus 2 Omicron variant predominance in community settings.
The study comprised the prospective assessment of coronavirus disease 2019 in the community trial participants, followed from 20 December 2021 to 28 June 2022, aged ≥5.0 years, and who were provided care by the Marshfield clinic health system . Surveys were distributed at recruitment to obtain data on age, gender, and comorbidities.
Antibodies eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Participants completed weekly symptom surveys, and nasal swabs were collected by self or parents when individuals developed ≥1.0 respiratory symptoms such as cough, fever, sore throat, smell loss, taste loss, muscle and/or body ache, diarrhea, or breathlessness. SARS-CoV-2 was detected in the specimens using reverse transcription polymerase chain reaction .
Among the participants, 59% and 41% received one and two booster doses, respectively. Relative VE was 51.0% favoring boosters over prime vaccinations, and showed no significant variation with prior COVID-19 history. Relative VE estimated were 74.0% at 15.0 days to 90.0 days following booster doses, reducing to 42.0% after 91.0 to 180.0 days, and 36.0% after 180.0 days. The relative VE for the second booster vs. the first booster was 24.0%.
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